Prof. Kilian Muñiz

Catalysis

Group Leader:
Kilian Muñiz, ICREA Professor

Administrative Support:
Sorania Jiménez

Postdoctoral Researchers:
Julien Bergès / Kang Chen (from Oct.)/ Sebastian Herold (until Oct.) / Mario David Martínez (until Oct.)

PhD Students:
Anastasia Tkacheva / Alexandra Eleni Bosnidou / Estefanía del Castillo Fernández / Daniel Fermin  Bafaluy Español / Thomas Lionel Gerard Duhamel / Èric Cots Fargas / Andrea Flores / Eleni Georgiou (from Oct) / María Belen García de la Concepción (until Sept.) / Bethany J. Groom

Master Students:
Oaikhena Zekeri Esezobor (Feb. – March) / Shahboz Yakubov (Feb. – March)

Visiting Students:
Cristian I. Suárez

Erasmus Students:
Ioanna Sideri (Sept. – Nov.)

Summary

The group of Prof. Muñiz deals with the discovery of new chemical transformations that provide direct access to molecules that contain nitrogen, which are key in a variety of compounds of biological and pharmaceutical interest. They have designed new hypomorphic iodine monomeric reagents that incorporate unprecedented iodine nitrogen links, resulting in a new enantioselective diaminization methodology. In addition, the group works on the expansion of the concept of halide oxidation chemistry. This research resulted in a series of amine reactions of non-functionalized C-H links catalysed by halides, providing access to nitrogenous aliphatic heterocycles not previously available.

Publications

‘Intramolecular Diamination of Alkenes’
K. Muñiz
BOOK CHAPTER
In: “Advances in Transition-Metal Mediated Heterocyclic Synthesis” edited by Daniel Sole, Israel Fernandez“, ACADEMIC PRESS LTD
ELSEVIER SCIENCE LTD, 2018, 33-53, (ISBN: 10.1016/B978-0-12-81)

‘Radical C-H-Amination of Heteroarenes using Dual Initiation by Visible Light and Iodine’
N. Lucchetti, A. Tkacheva, S. Fantasia, K. Muñiz
Adv Synth Catal. 2018, 360 (20), 3889-3893

‘Multiple Halogenation of Aliphatic C−H Bonds within the Hofmann–Löffler Manifold’
E. Del-Castillo, M. D. Martínez, A. E. Bosnidou, T. Duhamel, C. Q. O’Broin, H. Zhang, E. C. Escudero‐Adán, M. Martínez‐Belmonte, K. Muñiz
CHEM-EUR J 2018, 24 (65), 17225-1722

MORE PUBLICATIONS

‘An Electrophilic Bromine Redox Catalysis for the Synthesis of Indole Alkaloid Building Blocks by Selective Aliphatic C−H Amination’
J. Bergès, B. García, K. Muñiz
Angew. Chem. Int. Ed. 2018, 57 (48), 15891-15895

‘Promoting Intermolecular C-N Bond Formation under the Auspices of Iodine(III)’
K. Muñiz
Acc Chem Res. 2018, 51 (6), 1507-1519

‘Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines’
S. Herold, D. Bafaluy, K. Muñiz
Green Chem. 2018, 3191-3196

‘Designing Homogeneous Bromine Redox Catalysis for Selective Aliphatic C−H Bond Functionalization’
P. Becker, T. Duhamel, C. Martínez, K. Muñiz
Angew. Chem. Int. Ed. 2018, 57 (18), 5166-5170

‘Engineering Molecular Iodine Catalysis for Alkyl- Nitrogen Bond Formation’
T. Duhamel, C. J. Stein, C. Martínez, M. Reihe, K. Muñiz
ACS Catal. 2018, 8 (5), 3918–3925

‘Dual Intermolecular Allylic C-H Functionalization within the Tetrasubstituted Alkene Scaffold’
C. Martínez, K. Muñiz
Eur. J. Org. Chem. 2018, 2018 (10), 1248-1254

Projects

HalOx
Diseño de sistemas de oxidación basados en haluros para la formación de enlaces C-N
Ministerio | Ref: CTQ2017-88496-R
Proyectos I+D – Retos

CHAOS
C-H Activation in Organic Synthesis
COST-European Cooperation in Science and Technology | Ref: EU Cost Action 15106

Theses Supervised

Belén García
September 7th, 2018
Universitat Rovira i Virgili
Novel Halogen(I) Reagents in the Csp2- and Csp3-Bond Functionalization”